By Kazuo Kitamura, Kenji Kangawa, Tanenao Eto (auth.), Toshio Nishikimi MD, PhD (eds.)
Adrenomedullin was once stumbled on in 1993 in an extract of human pheochromocytoma whereas tracking cAMP degrees in rat platelets. Adrenomedullin has attracted enormous curiosity between cardiologists because of its impression at the cardiovascular process which incorporates a reduce in blood strain in vivo; an impression on vascular tender muscle cells; raises cAMP degrees; not directly reduces blood strain and has a job within the pathogenesis of arteriosclerosis.
Adrenomedullin in heart problems is an up to date assessment of the main correct facets of adrenomedullin. It includes a extensive variety of fields together with biochemistry, molecular biology, body structure, pharmacology, pathophysiology of heart problems and medical functions of adrenomedullin to cardiovascular disease.
Toshio Nishikimi, MD, PhD, is an affiliate Professor within the division of high blood pressure and Cardiorenal medication, Dokkyo college college of drugs, Tochigi, Japan.
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Additional info for Adrenomedullin in Cardiovascular Disease
1997) Direct cardiac and vascular actions of adrenomedullin in conscious sheep. Br JPharmacol 120:1179-1185. Pelengaris S, Khan M, and Evan G. (2002) c-MYC: more than just a matter of life and death. Nat Rev Cancer 2:764-776. Poyner DR, Sexton P M, Marshall I, Smith DM, Quirion R, Born W, Muff R, Fischer JA, and Foord SM. (2002) International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol Rev 54:233-246.
2. , 2002). , 1994a). Comparison between binding affinities and potencies of adenylate cyclase activity by synthetic AM analogs are summarized in Table 2. N-terminaltruncated derivatives, hAM-(13-52)-NH2 and hAM-(16-52)-NH2, both 21 retaining the cyclic structure and the amidated C-terminus showed comparable Ki and cAMP-generating activities to those of mature form hAM-(l-52)-NH2, whereas N-terminal fragment hAM-(l-10)-OH had no effect. These data indicate that N-terminal residues (1-15) of AM molecule are not essential for interaction with its receptor.
Boyden chamber). CONCLUDING REMARKS Expression of AM and its receptor has been shown to be not confined to cardiovascular system, but widely and ubiquitously distributed in variety of tissues. Since its discovery as a potent vasodilator, there have been extensive investigations revealing pleiotropic effects of AM. Recent discovery of CRLR/RAMP system that confers ligand selectivity for AM and CGRP facilitates the understanding of new-facet of AM/CGRP receptors and their signaling pathways. However, further characterization of CRLR/RAMP system is required to connect the missing link between molecular mechanism and experimental data of pleiotropic functions by AM.
Adrenomedullin in Cardiovascular Disease by Kazuo Kitamura, Kenji Kangawa, Tanenao Eto (auth.), Toshio Nishikimi MD, PhD (eds.)