Get An Introduction to Microbiology. Pharmaceutical Monographs PDF

By W. B. Hugo, J. B. Stenlake

ISBN-10: 0433156015

ISBN-13: 9780433156017

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A preparation containing streptodornase is in use in medicine to liquefy blood and pus. Coagulase, an enzyme produced by many staphylococci, increases the normal blood-clotting rate. The possession of coagulase activity is often taken as an index of pathogenicity in staphylococci but the exact role of coagulase in the pathogenicity of this organism is not at all clear. Other Toxic Substances and Complexes CL botulinum toxin. CL botulinum secretes a poison which is one of the most toxic substances known.

This group also produces toxins destroying white cells and red cells and an erythrogenic toxin which produces a characteristic red rash, as seen in cases of scarlet fever. Diphtheria toxin. The causal organism of diphtheria, Corynebacterium diphtheriae, produces a toxin which interferes with protein synthesis. Heart muscle is particularly sensitive. Cholera toxin. Causes an almost invariably fatal loss of fluid from the body tissues into the small intestine. This, in turn, causes a violent diarrhoea and dehydration of the body.

An initial stationary or lag phase. In typical instances this may be as little as 20 minutes, during which there is very little, if any, increase in the numbers of the viable population. The cells, however, are metabolically active in that they consume nutrients and increase in size, and are more susceptible to adverse conditions 9 Ί z LU a. CÛ < > LL O LU CÛ Z 3 Z O TIME (hours) FIG. 12. Bacterial growth curve. Escherichia coli in nutrient broth at 37° C. (A. D. D. thesis, University of Nottingham) such as extremes of temperature or the action of toxic substances than when actively growing.

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An Introduction to Microbiology. Pharmaceutical Monographs by W. B. Hugo, J. B. Stenlake


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